FERONIA cytoplasmic domain: node of varied signal outputs

Signal transduction by the Fat cytoplasmic domain.

The large atypical cadherin Fat is a receptor for both Hippo and planar cell polarity (PCP) pathways. Here we investigate the molecular basis for signal transduction downstream of Fat by creating targeted alterations within a genomic construct that contains the entire fat locus, and by monitoring and manipulating the membrane localization of the Fat pathway component Dachs. We establish that th...

Node Domain

Network models in OPNET are constructed from two broad classes of components: communication nodes and communication links. The internal structure of these objects, for the most part, is not visible at the network level. This chapter presents the methods used to specify the internal structure and therefore much of the capabilities of communication nodes. For a discussion of communication links, ...

Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor.

Neurons are highly polarized cells that must sort proteins synthesized in the cell body for transport into the axon or the dendrites. Given the amount of time and energy needed to deliver proteins to the distal processes, neurons must have high fidelity mechanisms that ensure proper polarized protein trafficking. Although a variety of proteins are localized either to the somatodendritic domain ...

Functional analysis of the cytoplasmic domain of the cytoplasmic domain of complement receptortype II (CR2/CD21)

Correlation between p33ING1b Cytoplasmic Transfer and Lymph Node Metastasis in Oral Squamous Cell Carcinoma

Background: Oral squamous cell carcinoma is the sixth most common malignancy in the world today.  ING1b/p33 is a newly-discovered tumor suppressor which enhances p53 activity. Transfer of p33 protein from nucleus to cytoplasmic compartment has been previously reported in leukemias. The objective of this study was to determine the correlation between p33ing1b cytoplasmic transfer and lymph node ...